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Attempts 127

What does the thyroid require in order to make T4?

  1. A
    Potassium
  2. B
    Iodine
  3. C
    Sodium
  4. D
    Magnesium

Topic Flashcards

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Question

What mineral is essential for the thyroid gland to produce T4 (thyroxine)?

Answer

Iodine is taken up by thyroid follicular cells and covalently bound to tyrosine in thyroglobulin to form T4 and T3.

Question

Without which element can the thyroid not synthesize thyroid hormones like T4?

Answer

Iodine. It provides the iodine atoms needed for the iodination of tyrosine, the key step in creating T4 (four iodine atoms) and T3 (three iodine atoms).

Question

What happens if the thyroid lacks sufficient iodine for making T4?

Answer

Reduced T4 and T3 production → hypothyroidism, goiter (enlarged thyroid trying to trap more iodine), and impaired metabolism/growth.

Question

How is iodine used in the biosynthesis of T4 in the thyroid?

Answer

Iodine is oxidized and added to tyrosine residues in thyroglobulin by thyroid peroxidase, forming mono- and di-iodotyrosine, which couple to create T4.

Question

Among Manganese, Iodine, Phosphorus, and Zinc, which one supports thyroid function by being a core element in hormone synthesis?

Answer

Iodine is the primary mineral used by the thyroid gland to build T3 and T4 hormones; the others have only indirect or supportive roles in thyroid activity.

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Is iodine a required building block for the synthesis of T4 in the thyroid?
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